Development of a Solid Self-emulsifying Drug Delivery System of Boswellia serrata

Pharmacognosy Research,2022,14,4,429-441.DOI:10.5530/pres.14.4.63Published:October 2022Type:Original ArticleAuthors:Vidhi Bhatia, and MS Arohi Paul Author(s) affiliations: Vidhi Bhatia*, Vivekanand Education Society’s College of Pharmacy Chembur, Mumbai, Maharashtra, INDIA. Abstract:Background: Self-emulsifying drug delivery system (SEDDS) solid-SEDDS Boswellia serrata extract (BSE) was aimed at overcoming the problems poor solubility bioavailability. Materials Methods: The formulation strategy included a selection oil phase, surfactant co-surfactant based on qualitative quantitative saturated studies. A ternary phase diagram constructed to identify self-emulsifying region using water uptake Pseudoternary diagrams were plotted 1:1, 2:1 3:1 ratios maximum micro-emulsification region. prepared formulations SEDDS evaluated for their physical appearance, stability, content, globule size determination. Solid-SEDDS by adsorption technique mannitol (4.5% w/w) size. In-vitro studies performed compare release solid drugs, S-SEDDS. Results: containing (200 mg), Capmul MCM C8 (15% w/w), Tween 20 (33.333% Transcutol HP (16.666% concluded be optimized. pattern signified more than 80% in 30 min case S-SEDDS SEDDS, 40% after 120 drug. may considered better oral dosage form as solidified are ideal liquid ones terms stability. Conclusion: Results suggest potential use improve dissolution hence bioavailability poorly water-soluble drugs like through route. Keywords:Bioavailability, serrata, Phase diagram, Solid-self-emulsifying systemView:PDF (1.56 MB)